Ginkgolide B( Bilobalide B | Ginkgolide B | BN 52021 )

Catalog No. M18066 CAS No. 15291-77-7

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HNMR

HPLC

MSDS

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Product Name

Ginkgolide B
Note

Research use only, not for human use.
Brief Description

Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
Description

Ginkgolide B is a GlyR agonist found in Ginkgo. It inhibits ATP release from thrombin-activated platelets, protects neurons against ischemic injury, prevents edema and inflammation, and increases activation of PKA, Ca+2 signaling, and glutamate release.
In Vitro

Western Blot Analysis Cell Line:HUVECs Concentration:30, 60, 150 μM Incubation Time:24 hResult:Inhibited the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α.RT-PCRCell Line:HUVECs Concentration:30, 60, 150 μM Incubation Time:24, 48 h Result:Increased CYP3A4 mRNA and MDR1 expression after 24 h, and this effect was dose-dependent after 48 h.
In Vivo

Animal Model:Male clean healthy Sprague-Dawley rats, weighing 250-280 g and aged 8 weeksDosage:20 mg/kg Administration:Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days Result:Decreased the neurological deficit score, increased the proportion of nestin-, neuron-specific enolase- and glial fibrillary acid protein-positive cells. Caused down-regulation of NSE protein at day 14.
Synonyms

Bilobalide B | Ginkgolide B | BN 52021
Pathway

Others
Target

Other Targets
Recptor

PAFR
Research Area

Others-Field
Indication

——

CAS Number

15291-77-7
Formula Weight

424.4
Molecular Formula

C20H24O10
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 30 mg/mL; 70.69 mM
SMILES

O1[C@H]2[C@@H](O)[C@]34[C@@H]5OC(=O)[C@]3(O[C@@H]3OC(=O)[C@H](O)[C@]43[C@H](C(C)(C)C)C5)[C@@]2(O)[C@H](C)C1=O
Chemical Name

5H-Dicyclopenta(b,c)furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-alpha5a,1,2,3,5,8-hexahydroxy-alpha3-methyl-, tri-gamma-lactone

1. Liu X, et al. Thromb Res. 2014 Nov;134(5):1066-73.

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